NOTCH1 is activated by DLL4 ligand expressed on a neighboring cell. The interaction of NOTCH1 and DLL4 is enhanced when NOTCH1 is glycosylated by fringe-enzymes. Based on mouse studies, activation of NOTCH1 by DLL4 may be important in angiogenesis (Benedito et al. 2009). DLL4 may also be involved in T-cell development. Mouse Dll4 is expressed on thymic epithelial cells and its interaction with Notch1 expressed on hematopoietic progenitors is necessary for T-cell lineage commitment (Koch et al. 2008, Hozumi et al. 2008).
Benedito, R, Roca, C, Sörensen, I, Adams, S, Gossler, A, Fruttiger, M, Adams, RH
Hozumi, K, Mailhos, C, Negishi, N, Hirano, K, Yahata, T, Ando, K, Zuklys, S, Holländer, GA, Shima, DT, Habu, S
Koch, U, Fiorini, E, Benedito, R, Besseyrias, V, Schuster-Gossler, K, Pierres, M, Manley, NR, Duarte, A, MacDonald, HR, Radtke, F
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