NOTCH1 binds DLL4

Stable Identifier
Reaction [binding]
Homo sapiens
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NOTCH1 is activated by DLL4 ligand expressed on a neighboring cell. The interaction of NOTCH1 and DLL4 is enhanced when NOTCH1 is glycosylated by fringe-enzymes. Based on mouse studies, activation of NOTCH1 by DLL4 may be important in angiogenesis (Benedito et al. 2009). DLL4 may also be involved in T-cell development. Mouse Dll4 is expressed on thymic epithelial cells and its interaction with Notch1 expressed on hematopoietic progenitors is necessary for T-cell lineage commitment (Koch et al. 2008, Hozumi et al. 2008).
Literature References
PubMed ID Title Journal Year
18824583 Delta-like 4 is indispensable in thymic environment specific for T cell development

Habu, S, Zuklys, S, Holländer, GA, Hozumi, K, Shima, DT, Hirano, K, Yahata, T, Negishi, N, Mailhos, C, Ando, K

J Exp Med 2008
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Adams, S, Gossler, A, Adams, RH, Fruttiger, M, Roca, C, Sörensen, I

Cell 2009
18824585 Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Radtke, F, MacDonald, HR, Fiorini, E, Pierres, M, Schuster-Gossler, K, Manley, NR, Benedito, R, Besseyrias, V, Duarte, A, Koch, U

J Exp Med 2008
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