Reactome | NOTCH1 binds DLL4

NOTCH1 binds DLL4

Stable Identifier

R-HSA-1980041

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NOTCH1 is activated by DLL4 ligand expressed on a neighboring cell. The interaction of NOTCH1 and DLL4 is enhanced when NOTCH1 is glycosylated by fringe-enzymes. Based on mouse studies, activation of NOTCH1 by DLL4 may be important in angiogenesis (Benedito et al. 2009). DLL4 may also be involved in T-cell development. Mouse Dll4 is expressed on thymic epithelial cells and its interaction with Notch1 expressed on hematopoietic progenitors is necessary for T-cell lineage commitment (Koch et al. 2008, Hozumi et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18824583	Delta-like 4 is indispensable in thymic environment specific for T cell development Hozumi, K, Mailhos, C, Negishi, N, Hirano, K, Yahata, T, Ando, K, Zuklys, S, Holländer, GA, Shima, DT, Habu, S	J Exp Med	2008
19524514	The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis Benedito, R, Roca, C, Sörensen, I, Adams, S, Gossler, A, Fruttiger, M, Adams, RH	Cell	2009
18824585	Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment Koch, U, Fiorini, E, Benedito, R, Besseyrias, V, Schuster-Gossler, K, Pierres, M, Manley, NR, Duarte, A, MacDonald, HR, Radtke, F	J Exp Med	2008