NOTCH1 is activated by DLL4 ligand expressed on a neighboring cell. The interaction of NOTCH1 and DLL4 is enhanced when NOTCH1 is glycosylated by fringe-enzymes. Based on mouse studies, activation of NOTCH1 by DLL4 may be important in angiogenesis (Benedito et al. 2009). DLL4 may also be involved in T-cell development. Mouse Dll4 is expressed on thymic epithelial cells and its interaction with Notch1 expressed on hematopoietic progenitors is necessary for T-cell lineage commitment (Koch et al. 2008, Hozumi et al. 2008).
Benedito, R, Adams, S, Gossler, A, Adams, RH, Fruttiger, M, Roca, C, Sörensen, I
Radtke, F, MacDonald, HR, Fiorini, E, Pierres, M, Schuster-Gossler, K, Manley, NR, Benedito, R, Besseyrias, V, Duarte, A, Koch, U
Habu, S, Zuklys, S, Holländer, GA, Hozumi, K, Shima, DT, Hirano, K, Yahata, T, Negishi, N, Mailhos, C, Ando, K
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