NOTCH1 binds DLL4

Stable Identifier
R-HSA-1980041
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NOTCH1 binds DLL4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NOTCH1 is activated by DLL4 ligand expressed on a neighboring cell. The interaction of NOTCH1 and DLL4 is enhanced when NOTCH1 is glycosylated by fringe-enzymes. Based on mouse studies, activation of NOTCH1 by DLL4 may be important in angiogenesis (Benedito et al. 2009). DLL4 may also be involved in T-cell development. Mouse Dll4 is expressed on thymic epithelial cells and its interaction with Notch1 expressed on hematopoietic progenitors is necessary for T-cell lineage commitment (Koch et al. 2008, Hozumi et al. 2008).

Literature References
PubMed ID Title Journal Year
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Roca, C, Sörensen, I, Adams, S, Gossler, A, Fruttiger, M, Adams, RH

Cell 2009
18824583 Delta-like 4 is indispensable in thymic environment specific for T cell development

Hozumi, K, Mailhos, C, Negishi, N, Hirano, K, Yahata, T, Ando, K, Zuklys, S, Holländer, GA, Shima, DT, Habu, S

J Exp Med 2008
18824585 Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

Koch, U, Fiorini, E, Benedito, R, Besseyrias, V, Schuster-Gossler, K, Pierres, M, Manley, NR, Duarte, A, MacDonald, HR, Radtke, F

J Exp Med 2008
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Inferred From
Dll4 binds Notch1 (Mus musculus)
Authored
Jassal, B  (2004-12-15)
Reviewed
Joutel, A  (2004-12-15)
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-09)