Reactome | hormone receptor negative mammary luminal progenitor cell

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hormone receptor negative mammary luminal progenitor cell Show undefined attributes

cellType	[CellType:9927427] progenitor cell of mammary luminal epithelium
consumedByEvent	[CellDevelopmentStep:R-HSA-9927438] Mammary hormone receptor negative luminal progenitor cell produces alveolar progenitor cell - Homo sapiens
created	[InstanceEdit:9927431] Orlic-Milacic, Marija, 2024-11-05
dbId	9927424
displayName	hormone receptor negative mammary luminal progenitor cell
inDisease	false
markerReference	[MarkerReference:9941898] MUC1(24-1255) [plasma membrane] Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue [MarkerReference:9960491] SLPI mRNA [cytosol] Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity [MarkerReference:9962948] EHF mRNA [cytosol] Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology [MarkerReference:9959959] EPCAM mRNA [cytosol] Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes [MarkerReference:9946807] KRT18 [cytosol] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9959924] ITGA6(24-1130) [plasma membrane] Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology [MarkerReference:9946418] KRT19 [cytosol] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9959921] MUC1 mRNA [cytosol] Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast [MarkerReference:9960561] SLPI [specific granule lumen] Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity [MarkerReference:9946844] KRT18 mRNA [cytosol] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9959900] KRT19 mRNA [cytosol] Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast [MarkerReference:9960443] ALDH1A3 mRNA [cytosol] A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast [MarkerReference:9946810] CD24(29-534) [plasma membrane] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9960442] KIT [plasma membrane] Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways [MarkerReference:9946809] CD24 mRNA [cytosol] Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation [MarkerReference:9960390] ELF5 mRNA [cytosol] A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast [MarkerReference:9960420] KIT mRNA [cytosol] A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast [MarkerReference:9941891] EPCAM [plasma membrane] Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue [MarkerReference:9962540] ITGA6 mRNA [cytosol] Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology [MarkerReference:9946850] CLDN4 mRNA [cytosol] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9964064] ALDH1A3 [cytosol] Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland [MarkerReference:9960558] ELF5 [nucleoplasm] Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity
maxDepth	2
modified	[InstanceEdit:9964293] Orlic-Milacic, Marija, 2025-08-21
name	hormone receptor negative mammary luminal progenitor cell luminal adaptive secretory precursor cell
organ	[Anatomy:9953066] mammary gland
producedByEvent	[CellDevelopmentStep:R-HSA-9927428] Mammary stem cell produces hormone receptor negative luminal progenitor cell - Homo sapiens
proteinMarker	[EntityWithAccessionedSequence:R-HSA-2980896] ALDH1A3 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-430062] CD24(27-59) [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9960557] ELF5 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-375068] EPCAM [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-204439] ITGA6(24-1130) [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-197662] KIT [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-201582] KRT18 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6809617] KRT19 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6793976] MUC1(24-1255) [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6799511] SLPI [specific granule lumen] - Homo sapiens
rNAMarker	[EntityWithAccessionedSequence:R-HSA-9944140] ALDH1A3 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9946812] CD24 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9946848] CLDN4 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9962944] EHF mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9960384] ELF5 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9944287] EPCAM mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9941923] ITGA6 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9960421] KIT mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9946845] KRT18 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9936327] KRT19 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9923412] MUC1 mRNA [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9960490] SLPI mRNA [cytosol] - Homo sapiens
schemaClass	Cell
species	[Species:48887] Homo sapiens
stId	R-HSA-9927424
tissue	[Anatomy:9953065] parenchyma of mammary gland

Referrals

(input)	[CellDevelopmentStep:R-HSA-9927438] Mammary hormone receptor negative luminal progenitor cell produces alveolar progenitor cell
(output)	[CellDevelopmentStep:R-HSA-9927428] Mammary stem cell produces hormone receptor negative luminal progenitor cell
(cell)	[MarkerReference:9941898] MUC1(24-1255) [plasma membrane] Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue [MarkerReference:9960491] SLPI mRNA [cytosol] Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity [MarkerReference:9962948] EHF mRNA [cytosol] Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology [MarkerReference:9959959] EPCAM mRNA [cytosol] Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes [MarkerReference:9946807] KRT18 [cytosol] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9959924] ITGA6(24-1130) [plasma membrane] Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology [MarkerReference:9946418] KRT19 [cytosol] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9959921] MUC1 mRNA [cytosol] Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast [MarkerReference:9960561] SLPI [specific granule lumen] Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity [MarkerReference:9946844] KRT18 mRNA [cytosol] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9959900] KRT19 mRNA [cytosol] Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast [MarkerReference:9960443] ALDH1A3 mRNA [cytosol] A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast [MarkerReference:9946810] CD24(29-534) [plasma membrane] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9960442] KIT [plasma membrane] Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways [MarkerReference:9946809] CD24 mRNA [cytosol] Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation [MarkerReference:9960390] ELF5 mRNA [cytosol] A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast [MarkerReference:9960420] KIT mRNA [cytosol] A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast [MarkerReference:9941891] EPCAM [plasma membrane] Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue [MarkerReference:9962540] ITGA6 mRNA [cytosol] Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology [MarkerReference:9946850] CLDN4 mRNA [cytosol] The CD10 enzyme is a key player to identify and regulate human mammary stem cells [MarkerReference:9964064] ALDH1A3 [cytosol] Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland [MarkerReference:9960558] ELF5 [nucleoplasm] Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity

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