Reactome | NADSYN1 hexamer amidates NAAD to NAD+

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NADSYN1 hexamer amidates NAAD to NAD+ Show undefined attributes

catalystActivity	[CatalystActivity:10243190] NAD+ synthase (glutamine-hydrolyzing) activity of NADSYN1 hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10243192
displayName	NADSYN1 hexamer amidates NAAD to NAD+
eventOf	[Pathway:R-CFA-196807] Nicotinate metabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ - Canis familiaris
goBiologicalProcess	[GO_BiologicalProcess:262876] 'de novo' NAD+ biosynthetic process from L-tryptophan
inferredFrom	[Reaction:R-HSA-197271] NADSYN1 hexamer amidates NAAD to NAD+ - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-197256] NAAD [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NADSYN1 hexamer amidates NAAD to NAD+ deamido-NAD(+) + L-glutamine + ATP + H2O => L-glutamate + AMP + diphosphate + NAD(+) + H(+) Amidation of deamino-NAD+ to NAD+
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-CFA-197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-197271
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-CFA-197198] NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+
(inferredTo)	[Reaction:R-HSA-197271] NADSYN1 hexamer amidates NAAD to NAD+

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