Reactome | RHO GTPases Activate Rhotekin and Rhophilins

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RHO GTPases Activate Rhotekin and Rhophilins Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
created	[InstanceEdit:5666186] Orlic-Milacic, Marija, 2015-01-21
dbId	5666185
displayName	RHO GTPases Activate Rhotekin and Rhophilins
edited	[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf	[Pathway:R-HSA-195258] RHO GTPase Effectors - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5666178] RTKN binds RHOA, RHOC or RHOB - Homo sapiens [Reaction:R-HSA-5666197] RHOA:GTP:RTKN binds LIN7B - Homo sapiens [Reaction:R-HSA-5666216] RHOA:GTP:RTKN binds TAX1BP3 - Homo sapiens [Reaction:R-HSA-5667008] RHOA:GTP binds RHPN1 or RHPN2 - Homo sapiens [Reaction:R-HSA-5667037] RHPN2 binds RHOB:GTP - Homo sapiens [Reaction:R-HSA-5667052] ROPN1 binds RHOA:GTP:RHPN1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5666179] Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain [LiteratureReference:5666194] Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286 [LiteratureReference:5666206] Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons [LiteratureReference:5666211] The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element [LiteratureReference:5667003] Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho [LiteratureReference:5667062] Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella [LiteratureReference:5667009] The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization [LiteratureReference:5667027] Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP [LiteratureReference:5672916] Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2 [LiteratureReference:5672924] Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis [LiteratureReference:5672982] Possible role of Rho/Rhotekin signaling in mammalian septin organization [LiteratureReference:5672992] SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling [LiteratureReference:5672988] Protein kinase D regulates RhoA activity via rhotekin phosphorylation
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RHO GTPases Activate Rhotekin and Rhophilins
orthologousEvent	[Pathway:R-CEL-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Caenorhabditis elegans [Pathway:R-DME-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Drosophila melanogaster [Pathway:R-GGA-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Gallus gallus [Pathway:R-XTR-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Xenopus tropicalis [Pathway:R-DRE-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Danio rerio [Pathway:R-SSC-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Sus scrofa [Pathway:R-BTA-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Bos taurus [Pathway:R-CFA-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Canis familiaris [Pathway:R-RNO-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Rattus norvegicus [Pathway:R-MMU-5666185] RHO GTPases Activate Rhotekin and Rhophilins - Mus musculus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5666185
summation	[Summation:5672366] Rhotekin (RTKN) is a protein with an N-terminally located RH...

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[Pathway:R-HSA-195258] RHO GTPase Effectors

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