Reactome | 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol

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4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol Show undefined attributes

catalystActivity	[CatalystActivity:10573956] C-4 methylsterol oxidase activity of MSMO1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10573958
displayName	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol
eventOf	[Pathway:R-DRE-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Danio rerio
inferredFrom	[Reaction:R-HSA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol - Homo sapiens
input	[SimpleEntity:R-ALL-194633] 14DMLANOL [endoplasmic reticulum membrane] 3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] 3 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol 4,4-dimethylcholesta-8(9),24-dien-3beta-ol + 3 NADPH + 3 H+ + 3 O2 => 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol + 3 NADP+ + 4 H2O
output	[SimpleEntity:R-ALL-194735] 4C4MZYMOL [endoplasmic reticulum membrane] 4 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-DRE-194678] CYP51A1 demethylates LAN - Danio rerio [Reaction:R-DRE-194698] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-194641
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(precedingEvent)	[Reaction:R-DRE-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one
(inferredTo)	[Reaction:R-HSA-194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol

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