Reactome | Axonal growth inhibition (RHOA activation)

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Axonal growth inhibition (RHOA activation) Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
created	[InstanceEdit:193693] Jassal, B, 2007-02-23 15:02:35
dbId	193634
displayName	Axonal growth inhibition (RHOA activation)
edited	[InstanceEdit:350668] Jassal, B, 2008-05-20 12:26:36
eventOf	[Pathway:R-HSA-193697] p75NTR regulates axonogenesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161083] negative regulation of axonogenesis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-193636] p75NTR interacts with the NOGO receptor - Homo sapiens [Reaction:R-HSA-209573] p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 - Homo sapiens [Reaction:R-HSA-193655] Myelin components can interact with p75NTR:NgR:LINGO1 - Homo sapiens [Reaction:R-HSA-9012761] The p75NTR:NgR:MDGI binds RHOA-GDI - Homo sapiens [Reaction:R-HSA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Homo sapiens [Reaction:R-HSA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:204355] Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Axonal growth inhibition (RHOA activation)
orthologousEvent	[Pathway:R-DRE-193634] Axonal growth inhibition (RHOA activation) - Danio rerio [Pathway:R-CEL-193634] Axonal growth inhibition (RHOA activation) - Caenorhabditis elegans [Pathway:R-DME-193634] Axonal growth inhibition (RHOA activation) - Drosophila melanogaster [Pathway:R-GGA-193634] Axonal growth inhibition (RHOA activation) - Gallus gallus [Pathway:R-SSC-193634] Axonal growth inhibition (RHOA activation) - Sus scrofa [Pathway:R-BTA-193634] Axonal growth inhibition (RHOA activation) - Bos taurus [Pathway:R-CFA-193634] Axonal growth inhibition (RHOA activation) - Canis familiaris [Pathway:R-RNO-193634] Axonal growth inhibition (RHOA activation) - Rattus norvegicus [Pathway:R-MMU-193634] Axonal growth inhibition (RHOA activation) - Mus musculus
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:350667] Friedman, WJ, 2008-05-20 12:23:46 [InstanceEdit:351795] Chao, MV, 2008-05-28 09:46:01
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-193634
summation	[Summation:194554] p75NTR can also form a receptor complex with the Nogo recept...
updateTrackers	[UpdateTracker:9788081] Update Tracker - [Pathway:193634] Axonal growth inhibition (RHOA activation) - v44:[updateContainedRLE] [UpdateTracker:9780833] Update Tracker - [Pathway:193634] Axonal growth inhibition (RHOA activation) - v62:[addHasEvent, updateContainedRLE] [UpdateTracker:9791736] Update Tracker - [Pathway:193634] Axonal growth inhibition (RHOA activation) - v26:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9788081] Update Tracker - [Pathway:193634] Axonal growth inhibition (RHOA activation) - v44:[updateContainedRLE] [UpdateTracker:9780833] Update Tracker - [Pathway:193634] Axonal growth inhibition (RHOA activation) - v62:[addHasEvent, updateContainedRLE] [UpdateTracker:9791736] Update Tracker - [Pathway:193634] Axonal growth inhibition (RHOA activation) - v26:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-193697] p75NTR regulates axonogenesis

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