Reactome | The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA

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The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:193693] Jassal, B, 2007-02-23 15:02:35
dbId	193696
displayName	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
edited	[InstanceEdit:350668] Jassal, B, 2008-05-20 12:26:36
eventOf	[Pathway:R-HSA-193634] Axonal growth inhibition (RHOA activation) - Homo sapiens
followingEvent	[Reaction:R-HSA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Homo sapiens
input	[Complex:R-HSA-194481] RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:194480] The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
orthologousEvent	[Reaction:R-DRE-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Danio rerio [Reaction:R-DME-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Drosophila melanogaster [Reaction:R-GGA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Gallus gallus [Reaction:R-SSC-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Sus scrofa [Reaction:R-BTA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Bos taurus [Reaction:R-CFA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Canis familiaris [Reaction:R-RNO-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Rattus norvegicus [Reaction:R-MMU-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Mus musculus
output	[Complex:R-HSA-194528] ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] [Complex:R-HSA-8964174] RHOA:GDP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9012761] The p75NTR:NgR:MDGI binds RHOA-GDI - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:350667] Friedman, WJ, 2008-05-20 12:23:46 [InstanceEdit:351795] Chao, MV, 2008-05-28 09:46:01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193696
summation	[Summation:194561] In the presence of a myelin component (GMDI), such as MAG, N...
updateTrackers	[UpdateTracker:9780713] Update Tracker - [Reaction:193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - v62:[add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780713] Update Tracker - [Reaction:193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - v62:[add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-193634] Axonal growth inhibition (RHOA activation)
(precedingEvent)	[Reaction:R-HSA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth