Reactome | RhoA is activated by nucleotide exchange and inhibits axonal growth

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RhoA is activated by nucleotide exchange and inhibits axonal growth Show undefined attributes

catalystActivity	[CatalystActivity:10242816] guanyl-nucleotide exchange factor activity of MCF2 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10242818
displayName	RhoA is activated by nucleotide exchange and inhibits axonal growth
eventOf	[Pathway:R-CFA-193634] Axonal growth inhibition (RHOA activation) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Homo sapiens
input	[Complex:R-CFA-8964174] RHOA:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RhoA is activated by nucleotide exchange and inhibits axonal growth
output	[Complex:R-CFA-5665993] RHOA:GTP [plasma membrane]
precedingEvent	[Reaction:R-CFA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-194518
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-193634] Axonal growth inhibition (RHOA activation)
(inferredTo)	[Reaction:R-HSA-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth

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