Reactome | CYP8B1 12-hydroxylates 4CHOL7aOLONE

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CYP8B1 12-hydroxylates 4CHOL7aOLONE Show undefined attributes

catalystActivity	[CatalystActivity:10463719] sterol 12-alpha-hydroxylase activity of CYP8B1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10463721
displayName	CYP8B1 12-hydroxylates 4CHOL7aOLONE
eventOf	[Pathway:R-SSC-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-192067] 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one - Sus scrofa
inferredFrom	[Reaction:R-HSA-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Homo sapiens
input	[SimpleEntity:R-ALL-192136] 4CHOL7aOLONE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP8B1 12-hydroxylates 4CHOL7aOLONE 7alpha-hydroxycholest-4-en-3-one + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) 4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one 7-alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 => 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O
output	[SimpleEntity:R-ALL-192195] 4CHOL7a,12aDONE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-SSC-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-192157
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Pathway:R-SSC-211994] Sterols are 12-hydroxylated by CYP8B1
(precedingEvent)	[Reaction:R-SSC-192067] 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one
(inferredTo)	[Reaction:R-HSA-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE

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