Reactome | Sterols are 12-hydroxylated by CYP8B1

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Sterols are 12-hydroxylated by CYP8B1 Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:211969] Jassal, B, 2008-02-08 15:33:52
dbId	211994
displayName	Sterols are 12-hydroxylated by CYP8B1
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:13620] sterol metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL - Homo sapiens [Reaction:R-HSA-193845] CYP8B1 12-hydroxylates 4CHOL7a,27DONE - Homo sapiens [Reaction:R-HSA-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-09-30
literatureReference	[LiteratureReference:192101] Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns
maxDepth	2
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Sterols are 12-hydroxylated by CYP8B1
orthologousEvent	[Pathway:R-GGA-211994] Sterols are 12-hydroxylated by CYP8B1 - Gallus gallus [Pathway:R-XTR-211994] Sterols are 12-hydroxylated by CYP8B1 - Xenopus tropicalis [Pathway:R-DRE-211994] Sterols are 12-hydroxylated by CYP8B1 - Danio rerio [Pathway:R-SSC-211994] Sterols are 12-hydroxylated by CYP8B1 - Sus scrofa [Pathway:R-CFA-211994] Sterols are 12-hydroxylated by CYP8B1 - Canis familiaris [Pathway:R-RNO-211994] Sterols are 12-hydroxylated by CYP8B1 - Rattus norvegicus [Pathway:R-MMU-211994] Sterols are 12-hydroxylated by CYP8B1 - Mus musculus
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19 [InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-211994
summation	[Summation:211931] Cytochrome P450 8B1 (CYP8B1, sterol 12-alpha- hydroxylase) h...
updateTrackers	[UpdateTracker:9779134] Update Tracker - [Pathway:211994] Sterols are 12-hydroxylated by CYP8B1 - v66:[updateContainedRLE] [UpdateTracker:9911074] Update Tracker - [Pathway:211994] Sterols are 12-hydroxylated by CYP8B1 - v89:[updateContainedRLE] [UpdateTracker:9786063] Update Tracker - [Pathway:211994] Sterols are 12-hydroxylated by CYP8B1 - v50:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9779134] Update Tracker - [Pathway:211994] Sterols are 12-hydroxylated by CYP8B1 - v66:[updateContainedRLE] [UpdateTracker:9911074] Update Tracker - [Pathway:211994] Sterols are 12-hydroxylated by CYP8B1 - v89:[updateContainedRLE] [UpdateTracker:9786063] Update Tracker - [Pathway:211994] Sterols are 12-hydroxylated by CYP8B1 - v50:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-211976] Endogenous sterols