CYP7A1 7-hydroxylates CHOL

Stable Identifier
R-HSA-192051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1, Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
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Cholesterol, NADPH + H+, and O2 form 7alpha-cholesterol (5-cholesten-3beta, 7alpha-diol), NADP+,and H2O, in a reaction catalysed by CYP7A1 (cholesterol 7alpha-hydroylase) in the endoplasmic reticulum membrane. In the body, this enzyme is expressed only in liver, and its expression is tightly regulated at the level of transcription to determine the overall rate of bile acid and bile salt production (Noshiro et al. 1990).

Literature References
PubMed ID Title Journal Year
2384150 Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase

Noshiro, M, Okuda, K

FEBS Lett 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cholesterol 7-alpha-monooxygenase activity of Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
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