Reactome | CYP7A1 7-hydroxylates CHOL

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CYP7A1 7-hydroxylates CHOL Show undefined attributes

catalystActivity	[CatalystActivity:10001300] cholesterol 7-alpha-monooxygenase activity of Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10001302
displayName	CYP7A1 7-hydroxylates CHOL
eventOf	[Pathway:R-MMU-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Mus musculus [Pathway:R-MMU-211976] Endogenous sterols - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one - Mus musculus
inferredFrom	[Reaction:R-HSA-192051] CYP7A1 7-hydroxylates CHOL - Homo sapiens
input	[SimpleEntity:R-ALL-193384] CHOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP7A1 7-hydroxylates CHOL cholesterol + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1 Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
output	[SimpleEntity:R-ALL-192114] 7 alpha-hydroxycholesterol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-MMU-5340195] NR1H4 binds DCA, CDCA, LCHA - Mus musculus
regulatedBy	[NegativeRegulation:10001229] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-192051
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Pathway:R-MMU-211976] Endogenous sterols
(precedingEvent)	[Reaction:R-MMU-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
(inferredTo)	[Reaction:R-HSA-192051] CYP7A1 7-hydroxylates CHOL

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