27-hydroxycholesterol is 7alpha-hydroxylated

Stable Identifier
R-HSA-191972
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
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27-hydroxycholesterol, NADPH + H+, and O2 react to form cholest-5-ene-3beta,7alpha,27-triol, H2O, and NADP+. This reaction is catalyzed by CYP7B1 in the endoplasmic reticulum membrane. Defects in CYB7B1 are associated with failure of 7alpha-hydroxylation in vivo, and with liver damage, confirming both the function of the enzyme and the central role of the liver in this metabolic process (Setchell et al. 1998).

Literature References
PubMed ID Title Journal Year
10588945 Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1

Wu, Z, Martin, KO, Javitt, NB, Chiang, JY

J Lipid Res 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
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Created
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