Reactome | 27-hydroxycholesterol is 7alpha-hydroxylated

27-hydroxycholesterol is 7alpha-hydroxylated

Stable Identifier

R-HSA-191972

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Bile acid and bile salt metabolism (Homo sapiens)
      - Synthesis of bile acids and bile salts (Homo sapiens)
        
        Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
        
        27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)

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27-hydroxycholesterol is 7alpha-hydroxylated

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27-hydroxycholesterol, NADPH + H+, and O2 react to form cholest-5-ene-3beta,7alpha,27-triol, H2O, and NADP+. This reaction is catalyzed by CYP7B1 in the endoplasmic reticulum membrane. Defects in CYB7B1 are associated with failure of 7alpha-hydroxylation in vivo, and with liver damage, confirming both the function of the enzyme and the central role of the liver in this metabolic process (Setchell et al. 1998).

Literature References