Reactome | 27-hydroxycholesterol is 7alpha-hydroxylated

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27-hydroxycholesterol is 7alpha-hydroxylated Show undefined attributes

catalystActivity	[CatalystActivity:10348992] oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10349014
displayName	27-hydroxycholesterol is 7alpha-hydroxylated
eventOf	[Pathway:R-BTA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Bos taurus
inferredFrom	[Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Homo sapiens
input	[SimpleEntity:R-ALL-176617] 27HCHOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	27-hydroxycholesterol is 7alpha-hydroxylated 27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
output	[SimpleEntity:R-ALL-192194] Cholest-5-ene-3beta,7alpha,27-triol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-BTA-5340195] NR1H4 binds DCA, CDCA, LCHA - Bos taurus
regulatedBy	[NegativeRegulation:10349015] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-191972
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(precedingEvent)	[Reaction:R-BTA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one
(inferredTo)	[Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated

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