Reactome | Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one

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Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one Show undefined attributes

authored	[InstanceEdit:193805] D'Eustachio, P, 2007-02-27 21:49:11
catalystActivity	[CatalystActivity:192106] 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity of HSD3B7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193803] D'Eustachio, P, 2007-02-27 22:01:10
dbId	193816
displayName	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one
edited	[InstanceEdit:193805] D'Eustachio, P, 2007-02-27 21:49:11
eventOf	[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol - Homo sapiens
followingEvent	[Reaction:R-HSA-193824] 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one - Homo sapiens [Reaction:R-HSA-193845] CYP8B1 12-hydroxylates 4CHOL7a,27DONE - Homo sapiens
input	[SimpleEntity:R-ALL-192194] Cholest-5-ene-3beta,7alpha,27-triol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:193374] Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease [LiteratureReference:193532] The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one Cholest-5-ene-3beta,7alpha,27-triol + NAD+ => 4-cholesten-7alpha,27-diol-3-one +NADH + H+
orthologousEvent	[Reaction:R-DME-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Drosophila melanogaster [Reaction:R-XTR-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Xenopus tropicalis [Reaction:R-DRE-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Danio rerio [Reaction:R-SSC-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Sus scrofa [Reaction:R-BTA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Bos taurus [Reaction:R-CFA-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Canis familiaris [Reaction:R-RNO-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Rattus norvegicus [Reaction:R-MMU-193816] Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one - Mus musculus
output	[SimpleEntity:R-ALL-193835] 4CHOL7a,27DONE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-HSA-191972] 27-hydroxycholesterol is 7alpha-hydroxylated - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193816
summation	[Summation:193797] Cholest-5-ene-3beta,7alpha,27-triol and NAD+ react to form 4...

Referrals

(hasEvent)	[Pathway:R-HSA-193807] Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(precedingEvent)	[Reaction:R-HSA-193824] 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one [Reaction:R-HSA-193845] CYP8B1 12-hydroxylates 4CHOL7a,27DONE