Reactome | Squalene is oxidized to its epoxide

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Squalene is oxidized to its epoxide Show undefined attributes

authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:191350] squalene monooxygenase activity of SQLE:FAD [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:9945093] RHEA:25282
dbId	191299
displayName	Squalene is oxidized to its epoxide
eventOf	[Pathway:R-HSA-9969896] Lanosterol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-191269] SQNE [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191271] Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Squalene is oxidized to its epoxide squalene + reduced (NADPH--hemoprotein reductase) + O2 = (S)-2,3-epoxysqualene + oxidized (NADPH--hemoprotein reductase) + H2O + H(+)
orthologousEvent	[Reaction:R-SCE-191299] Squalene is oxidized to its epoxide - Saccharomyces cerevisiae [Reaction:R-SPO-191299] Squalene is oxidized to its epoxide - Schizosaccharomyces pombe [Reaction:R-DDI-191299] Squalene is oxidized to its epoxide - Dictyostelium discoideum [Reaction:R-GGA-191299] Squalene is oxidized to its epoxide - Gallus gallus [Reaction:R-XTR-191299] Squalene is oxidized to its epoxide - Xenopus tropicalis [Reaction:R-DRE-191299] Squalene is oxidized to its epoxide - Danio rerio [Reaction:R-SSC-191299] Squalene is oxidized to its epoxide - Sus scrofa [Reaction:R-BTA-191299] Squalene is oxidized to its epoxide - Bos taurus [Reaction:R-CFA-191299] Squalene is oxidized to its epoxide - Canis familiaris [Reaction:R-RNO-191299] Squalene is oxidized to its epoxide - Rattus norvegicus [Reaction:R-MMU-191299] Squalene is oxidized to its epoxide - Mus musculus
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-191309] SQOX [cytosol]
precedingEvent	[Reaction:R-HSA-191402] Reduction of presqualene diphosphate to form squalene - Homo sapiens
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-191299
summation	[Summation:191284] Squalene monooxygenase (squalene epoxidase, SE) is located o...
updateTrackers	[UpdateTracker:9971903] Update Tracker - [Reaction:191299] Squalene is oxidized to its epoxide - v95:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9971903] Update Tracker - [Reaction:191299] Squalene is oxidized to its epoxide - v95:[modifyText]
(hasEvent)	[Pathway:R-HSA-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-HSA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol

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