Reactome | Squalene 2,3-epoxide cyclizes, forming lanosterol

Squalene 2,3-epoxide cyclizes, forming lanosterol

Stable Identifier

R-HSA-191366

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

(S)-2,3-epoxysqualene => lanosterol

ReviewStatus

5/5

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Squalene 2,3-epoxide cyclizes, forming lanosterol

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Lanosterol synthase (LSS) catalyzes the cyclization of squalene 2,3-epoxide to lanosterol, a reaction that forms the sterol nucleus (Sung et al. 1995; Van Tamelen et al. 1966). LSS is located on the ER membrane and is active in monomeric form (Ruf et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
8593458	Molecular cloning of cDNA encoding human lanosterol synthase Sung, CK, Shibuya, M, Sankawa, U, Ebizuka, Y	Biol Pharm Bull	1995
5918048	Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol Van Tamelen, EE, Willett, JD, Clayton, RB, Lord, KE	J Am Chem Soc	1966
14766201	The monotopic membrane protein human oxidosqualene cyclase is active as monomer Ruf, A, Muller, F, D'Arcy, B, Stihle, M, Kusznir, E, Handschin, C, Morand, OH, Thoma, R	Biochem Biophys Res Commun	2004