Reactome | Squalene 2,3-epoxide cyclizes, forming lanosterol

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Squalene 2,3-epoxide cyclizes, forming lanosterol Show undefined attributes

catalystActivity	[CatalystActivity:10241957] lanosterol synthase activity of LSS [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10241959
displayName	Squalene 2,3-epoxide cyclizes, forming lanosterol
eventOf	[Pathway:R-CFA-9969896] Lanosterol biosynthesis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-194678] CYP51A1 demethylates LAN - Canis familiaris [Reaction:R-CFA-9755937] DHCR24 reduces LAN to 24,25-dhLAN - Canis familiaris
inferredFrom	[Reaction:R-HSA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Homo sapiens
input	[SimpleEntity:R-ALL-191309] SQOX [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Squalene 2,3-epoxide cyclizes, forming lanosterol (S)-2,3-epoxysqualene => lanosterol
output	[SimpleEntity:R-ALL-194634] LAN [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-CFA-191299] Squalene is oxidized to its epoxide - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-191366
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-CFA-194678] CYP51A1 demethylates LAN [Reaction:R-CFA-9755937] DHCR24 reduces LAN to 24,25-dhLAN
(inferredTo)	[Reaction:R-HSA-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol

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