p53 positively regulates transcription of MIR34 microRNAs

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Reaction [BlackBoxEvent]
Homo sapiens
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Transcription of microRNA MIR34A is directly induced by the tumor suppressor p53, which binds to the conserved p53 binding site located in the vicinity of the MIR34A transcription start (Chang et al. 2007, Raver-Shapira et al. 2007). Genomic loss of the chromosomal band 1p36, harboring the MIR34A gene, is a frequent event in pancreatic cancer, and MIR34A is considered to act as a tumor suppressor. Conserved p53 binding sites were also mapped to the promoter of clustered MIR34B and MIR34C genes, and the transcription of MIR34B and MIR34C microRNAs was shown to be positively regulated by p53 (He et al. 2007, Corney et al. 2007). The steps involved in processing of pri-microRNA into pre-microRNA have been omitted in this event - please refer to the diagram of Regulatory RNA Pathways for details.

Literature References
PubMed ID Title Journal Year
17823410 MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth

Corney, DC, Flesken-Nikitin, A, Godwin, AK, Wang, W, Nikitin, AY

Cancer Res 2007
17540598 Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

Raver-Shapira, N, Marciano, E, Meiri, E, Spector, Y, Rosenfeld, N, Moskovits, N, Bentwich, Z, Oren, M

Mol Cell 2007
17554337 A microRNA component of the p53 tumour suppressor network

He, L, He, X, Lim, LP, de Stanchina, E, Xuan, Z, Liang, Y, Xue, W, Zender, L, Magnus, J, Ridzon, D, Jackson, AL, Linsley, PS, Chen, C, Lowe, SW, Cleary, MA, Hannon, GJ

Nature 2007
17540599 Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

Chang, TC, Wentzel, EA, Kent, OA, Ramachandran, K, Mullendore, M, Lee, KH, Feldmann, G, Yamakuchi, M, Ferlito, M, Lowenstein, CJ, Arking, DE, Beer, MA, Maitra, A, Mendell, JT

Mol Cell 2007
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