Reactome | Fringe-modified Pre-NOTCH is cleaved by FURIN

Fringe-modified Pre-NOTCH is cleaved by FURIN

Stable Identifier

R-HSA-1912372

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Fringe-modified Pre-NOTCH is cleaved by FURIN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cleavage of fringe-modified NOTCH by FURIN has not been examined directly, but since mature, plasma membrane-anchored NOTCH receptors are typically cleaved by FURIN (Blaumueller et al. 1997) and fringe-modified NOTCH functions at the cell surface (Moloney et al. 2000), it is expected that fringe-modified NOTCH is processed by FURIN cleavage. The exact order of fringe-mediated glycosylation and FURIN cleavage has not been experimentally established, but since FURIN localizes to the trans-Golgi network -TGN (Teuchert et al. 1999), while fringe has not been associated with TGN, it is likely that modification of NOTCH by fringe enzymes precedes FURIN-mediated cleavage.

Literature References

PubMed ID	Title	Journal	Year
10075724	Sorting of furin at the trans-Golgi network. Interaction of the cytoplasmic tail sorting signals with AP-1 Golgi-specific assembly proteins Hoflack, B, Klenk, HD, Garten, W, Schäfer, W, Berghöfer, S, Teuchert, M	J Biol Chem	1999
10935626	Fringe is a glycosyltransferase that modifies Notch Shao, L, Wang, Y, Johnston, SH, Irvine, KD, Stanley, P, Haltiwanger, RS, Moloney, DJ, Wilson, R, Chen, J, Vogt, TF, Panin, VM	Nature	2000
9244302	Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane Artavanis-Tsakonas, S, Zagouras, P, Qi, H, Blaumueller, CM	Cell	1997