Reactome | FGFR1c binds to FGF

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FGFR1c binds to FGF Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:190255] de Bono, B, 2006-12-18 15:58:02
dbId	190256
diseaseReaction	[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity - Homo sapiens
displayName	FGFR1c binds to FGF
eventOf	[Pathway:R-HSA-190373] FGFR1c ligand binding and activation - Homo sapiens
followingEvent	[Reaction:R-HSA-190429] Autocatalytic phosphorylation of FGFR1c - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-189897] FGFR1c [plasma membrane] 2 × [DefinedSet:R-HSA-189953] FGFR1c-binding FGFs [extracellular region] [SimpleEntity:R-ALL-190915] HS [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:190251] Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. [LiteratureReference:191519] Structural basis for fibroblast growth factor receptor activation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	FGFR1c binds to FGF
orthologousEvent	[Reaction:R-CEL-190256] FGFR1c binds to FGF - Caenorhabditis elegans [Reaction:R-DME-190256] FGFR1c binds to FGF - Drosophila melanogaster [Reaction:R-GGA-190256] FGFR1c binds to FGF - Gallus gallus [Reaction:R-XTR-190256] FGFR1c binds to FGF - Xenopus tropicalis [Reaction:R-DRE-190256] FGFR1c binds to FGF - Danio rerio [Reaction:R-SSC-190256] FGFR1c binds to FGF - Sus scrofa [Reaction:R-BTA-190256] FGFR1c binds to FGF - Bos taurus [Reaction:R-CFA-190256] FGFR1c binds to FGF - Canis familiaris [Reaction:R-RNO-190256] FGFR1c binds to FGF - Rattus norvegicus [Reaction:R-MMU-190256] FGFR1c binds to FGF - Mus musculus
output	[Complex:R-HSA-190233] FGFR1c homodimer bound to FGF [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-480515] Expression of FGF2 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[Requirement:R-HSA-190311] Requirement by 'HS [extracellular region]' [NegativeRegulation:R-HSA-5654431] Negative regulation by 'FGFR1c:KAL1 [plasma membrane]' [PositiveRegulation:R-HSA-5654433] Positive regulation by 'KAL1:HS [extracellular region]' [PositiveRegulation:9839338] Positive regulation by 'FGF2:TGFBR3:GIPC1'
regulationReference	[RegulationReference:9840936] Positive regulation by 'FGF2:TGFBR3:GIPC1' Binding of two growth factor families to separate domains of the proteoglycan betaglycan
releaseDate	2007-02-28
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-190256
summation	[Summation:191578] In this reaction, FGF receptor in the plasma membrane binds ...
updateTrackers	[UpdateTracker:9842283] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v86:[addRegulator, modifyText] [UpdateTracker:9789711] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v37:[addLiteratureReference, add_removeInput, removeRegulator] [UpdateTracker:9789014] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v39:[add_removeRegulator] [UpdateTracker:9785332] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v52:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9842283] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v86:[addRegulator, modifyText] [UpdateTracker:9789711] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v37:[addLiteratureReference, add_removeInput, removeRegulator] [UpdateTracker:9789014] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v39:[add_removeRegulator] [UpdateTracker:9785332] Update Tracker - [Reaction:190256] FGFR1c binds to FGF - v52:[addRegulator]
(normalReaction)	[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity
(hasEvent)	[Pathway:R-HSA-190373] FGFR1c ligand binding and activation
(precedingEvent)	[Reaction:R-HSA-190429] Autocatalytic phosphorylation of FGFR1c

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