Reactome | FGFR1c binds to FGF

Schema > Reaction > Entries

FGFR1c binds to FGF Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10663327
displayName	FGFR1c binds to FGF
eventOf	[Pathway:R-XTR-190373] FGFR1c ligand binding and activation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-190429] Autocatalytic phosphorylation of FGFR1c - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-190256] FGFR1c binds to FGF - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-XTR-189897] FGFR1c [plasma membrane] 2 × [DefinedSet:R-XTR-189953] FGFR1c-binding FGFs [extracellular region] [SimpleEntity:R-ALL-190915] HS [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	FGFR1c binds to FGF
output	[Complex:R-XTR-190233] FGFR1c homodimer bound to FGF [plasma membrane]
regulatedBy	[Requirement:R-HSA-190316] Requirement by 'HS [extracellular region]' [NegativeRegulation:10663328] Negative regulation by 'FGFR1c:KAL1 [plasma membrane]' [PositiveRegulation:10663329] Positive regulation by 'KAL1:HS [extracellular region]' [PositiveRegulation:10663311] Positive regulation by 'FGF2:TGFBR3:GIPC1'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-190256
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-190373] FGFR1c ligand binding and activation
(precedingEvent)	[Reaction:R-XTR-190429] Autocatalytic phosphorylation of FGFR1c
(inferredTo)	[Reaction:R-HSA-190256] FGFR1c binds to FGF