FGFR1c binds to FGF

Stable Identifier
Reaction [binding]
Homo sapiens
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In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Also, TGFBR3 (beta-glycan) facilitates the binding of FGF2 with its receptor FGFR1 by binding with FGF2 itself and bringing more ligands into receptor proximity (Andres et al. 1992, Knelson et al. 2013).

Literature References
PubMed ID Title Journal Year
15863029 Structural basis for fibroblast growth factor receptor activation

Olsen, SK, Mohammadi, M, Ibrahimi, OA

Cytokine Growth Factor Rev 2005
16597617 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Ornitz, DM, Umemori, H, Mohammadi, M, Olsen, SK, Ibrahimi, OA, Zhang, X

J Biol Chem 2006
This event is regulated