Reactome | In this reaction, FGF receptor in the plasma membrane binds ...

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created	[InstanceEdit:191576] de Bono, B, 2007-01-20 18:41:10
dbId	191578
displayName	In this reaction, FGF receptor in the plasma membrane binds ...
literatureReference	[LiteratureReference:9840155] Binding of two growth factor families to separate domains of the proteoglycan betaglycan [LiteratureReference:9840062] Type III TGF-? receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma
modified	[InstanceEdit:9842182] Orlic-Milacic, Marija, 2023-08-21
schemaClass	Summation
text	In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Also, TGFBR3 (beta-glycan) facilitates the binding of FGF2 with its receptor FGFR1 by binding with FGF2 itself and bringing more ligands into receptor proximity (Andres et al. 1992, Knelson et al. 2013).

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