Reactome | Autocatalytic phosphorylation of FGFR1c

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Autocatalytic phosphorylation of FGFR1c Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:190431] protein tyrosine kinase activity of FGFR1c homodimer bound to FGF [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:190433] de Bono, B, 2007-01-02 16:43:07
dbId	190429
diseaseReaction	[Reaction:R-HSA-2023455] Autocatalytic phosphorylation of FGFR1c P252X mutant dimers - Homo sapiens
displayName	Autocatalytic phosphorylation of FGFR1c
eventOf	[Pathway:R-HSA-190373] FGFR1c ligand binding and activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5656064] Activated FGFR1 binds FLRT1,2,3 - Homo sapiens [Reaction:R-HSA-5654571] Activated FGFR1 binds FRS3 - Homo sapiens [Reaction:R-HSA-5654573] Activated FGFR1 binds SHC1 - Homo sapiens [Reaction:R-HSA-5654167] Activated FGFR1 binds PLCG1 - Homo sapiens [Reaction:R-HSA-5654569] Activated FGFR1 binds FRS2 - Homo sapiens
input	16 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-190233] FGFR1c homodimer bound to FGF [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:201396] Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors [LiteratureReference:190962] Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation [LiteratureReference:443277] Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction [LiteratureReference:190942] Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction [LiteratureReference:1295588] Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Autocatalytic phosphorylation of FGFR1c
orthologousEvent	[Reaction:R-CEL-190429] Autocatalytic phosphorylation of FGFR1c - Caenorhabditis elegans [Reaction:R-DME-190429] Autocatalytic phosphorylation of FGFR1c - Drosophila melanogaster [Reaction:R-GGA-190429] Autocatalytic phosphorylation of FGFR1c - Gallus gallus [Reaction:R-XTR-190429] Autocatalytic phosphorylation of FGFR1c - Xenopus tropicalis [Reaction:R-DRE-190429] Autocatalytic phosphorylation of FGFR1c - Danio rerio [Reaction:R-SSC-190429] Autocatalytic phosphorylation of FGFR1c - Sus scrofa [Reaction:R-BTA-190429] Autocatalytic phosphorylation of FGFR1c - Bos taurus [Reaction:R-CFA-190429] Autocatalytic phosphorylation of FGFR1c - Canis familiaris [Reaction:R-RNO-190429] Autocatalytic phosphorylation of FGFR1c - Rattus norvegicus [Reaction:R-MMU-190429] Autocatalytic phosphorylation of FGFR1c - Mus musculus
output	[Complex:R-HSA-190425] Activated FGFR1c homodimer [plasma membrane] 16 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-190256] FGFR1c binds to FGF - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-190429
summation	[Summation:191577] Studies have mapped 8 tyrosine residues in the cytoplasmic d...
updateTrackers	[UpdateTracker:9792232] Update Tracker - [Reaction:190429] Autocatalytic phosphorylation of FGFR1c - v22:[addLiteratureReference, modifyText] [UpdateTracker:9789541] Update Tracker - [Reaction:190429] Autocatalytic phosphorylation of FGFR1c - v37:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9792232] Update Tracker - [Reaction:190429] Autocatalytic phosphorylation of FGFR1c - v22:[addLiteratureReference, modifyText] [UpdateTracker:9789541] Update Tracker - [Reaction:190429] Autocatalytic phosphorylation of FGFR1c - v37:[addLiteratureReference, modifyText]
(normalReaction)	[Reaction:R-HSA-2023455] Autocatalytic phosphorylation of FGFR1c P252X mutant dimers
(hasEvent)	[Pathway:R-HSA-190373] FGFR1c ligand binding and activation
(precedingEvent)	[Reaction:R-HSA-5656064] Activated FGFR1 binds FLRT1,2,3 [Reaction:R-HSA-5654571] Activated FGFR1 binds FRS3 [Reaction:R-HSA-5654573] Activated FGFR1 binds SHC1 [Reaction:R-HSA-5654167] Activated FGFR1 binds PLCG1 [Reaction:R-HSA-5654569] Activated FGFR1 binds FRS2

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