Reactome | Flagellin binds to TLR5

Schema > Reaction > Entries

Flagellin binds to TLR5 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:188026] de Bono, B, 2006-09-30 08:32:54
dbId	188025
displayName	Flagellin binds to TLR5
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-168176] Toll Like Receptor 5 (TLR5) Cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-975866] MyD88 forms a complex with the activated TLR receptor - Homo sapiens
input	[EntityWithAccessionedSequence:R-ECO-167919] Flagellin [extracellular region] 2 × [EntityWithAccessionedSequence:R-HSA-168013] TLR5 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:180969] Inferences, questions and possibilities in Toll-like receptor signalling [LiteratureReference:188036] AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2 [LiteratureReference:188053] The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 [LiteratureReference:180965] Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Flagellin binds to TLR5
output	[Complex:R-HSA-188027] TLR5 homodimer:bacterial flagellin [plasma membrane]
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188962] Gale M, Jr, 2006-10-31 16:45:01 [InstanceEdit:1186998] Gillespie, ME, 2011-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-188025
summation	[Summation:188739] Fragments of extracelllar flagellin bind the TLR5 homodimer.

Referrals

(hasEvent)	[Pathway:R-HSA-168176] Toll Like Receptor 5 (TLR5) Cascade
(precedingEvent)	[Reaction:R-HSA-975866] MyD88 forms a complex with the activated TLR receptor