Flagellin binds to TLR5

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Escherichia coli
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Fragments of extracelllar flagellin bind the TLR5 homodimer.

Literature References
PubMed ID Title Journal Year
15241424 Inferences, questions and possibilities in Toll-like receptor signalling

Beutler, B

Nature 2004
12807870 Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells

Ding, S, Ryan, K, Smith MF, Jr, Li, G, Fitzmaurice, AM, Crowe, S, Mitchell, A, Goldberg, JB

J Biol Chem 2003
11323673 The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Smith, KD, Underhill, DM, Hawn, TR, Goodlett, DR, Ozinsky, A, Aderem, A, Akira, S, Eng, JK, Yi, EC, Hayashi, F

Nature 2001
16439799 AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2

Basbaum, C, Gallup, M, McNamara, N, McKemy, D, Sucher, A, Maltseva, I

Am J Respir Cell Mol Biol 2006
Cite Us!