Reactome | MyD88 forms a complex with the activated TLR receptor

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MyD88 forms a complex with the activated TLR receptor Show undefined attributes

authored	[InstanceEdit:975890] Shamovsky, V, 2010-10-06
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:975863] Shamovsky, V, 2010-10-06
dbId	975866
displayName	MyD88 forms a complex with the activated TLR receptor
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-975880] MyD88 oligomerization within the complex of activated TLR:MyD88 - Homo sapiens
input	[DefinedSet:R-HSA-975862] Activated TLR5 or TLR10 homodimer [plasma membrane] 2 × [EntityWithAccessionedSequence:R-HSA-166059] MYD88 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165868] MyD88: an adapter that recruits IRAK to the IL-1 receptor complex [LiteratureReference:166234] The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MyD88 forms a complex with the activated TLR receptor
output	[Complex:R-HSA-975860] MyD88 complexed with the activated TLR5 or 10 receptor [plasma membrane]
precedingEvent	[Reaction:R-HSA-188025] Flagellin binds to TLR5 - Homo sapiens [BlackBoxEvent:R-HSA-168947] Ligand binds to TLR10 - Homo sapiens
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1186998] Gillespie, ME, 2011-02-10 [InstanceEdit:1474057] Li, L, 2011-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975866
summation	[Summation:975889] MyD88 is the downstream adaptor which is utilized by all TLR...

Referrals

(hasEvent)	[Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane
(precedingEvent)	[Reaction:R-HSA-975880] MyD88 oligomerization within the complex of activated TLR:MyD88

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