Reactome | Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21

Schema > Reaction > Entries

Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 Show undefined attributes

catalystActivity	[CatalystActivity:10663029] cyclin-dependent protein serine/threonine kinase activity of Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10663031
displayName	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
eventOf	[Pathway:R-XTR-187577] SCF(Skp2)-mediated degradation of p27/p21 - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-XTR-187516] Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-XTR-187522] Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm]
precedingEvent	[Reaction:R-XTR-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Xenopus tropicalis [Reaction:R-XTR-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-187520
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-187577] SCF(Skp2)-mediated degradation of p27/p21
(inferredTo)	[Reaction:R-HSA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21

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