Reactome | PDGF-BB clevage by Furin

Schema > Reaction > Entries

PDGF-BB clevage by Furin Show undefined attributes

authored	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
catalystActivity	[CatalystActivity:156993] serine-type endopeptidase activity of FURIN [Golgi membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:20699] Golgi membrane
created	[InstanceEdit:8865277] Garapati, Phani Vijay, 2016-03-21
dbId	8865275
displayName	PDGF-BB clevage by Furin
edited	[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008-11-24 10:14:27
eventOf	[Pathway:R-HSA-186797] Signaling by PDGF - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-186773] PDGF dimer binds two receptors simultaneously - Homo sapiens
input	[Complex:R-HSA-380748] proPDGF-BB dimer [Golgi membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380776] PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly [LiteratureReference:380726] The PDGF family: four gene products form five dimeric isoforms [LiteratureReference:380730] Mechanism of action and in vivo role of platelet-derived growth factor
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PDGF-BB clevage by Furin
orthologousEvent	[Reaction:R-CEL-8865275] PDGF-BB clevage by Furin - Caenorhabditis elegans [Reaction:R-DME-8865275] PDGF-BB clevage by Furin - Drosophila melanogaster [Reaction:R-GGA-8865275] PDGF-BB clevage by Furin - Gallus gallus [Reaction:R-XTR-8865275] PDGF-BB clevage by Furin - Xenopus tropicalis [Reaction:R-DRE-8865275] PDGF-BB clevage by Furin - Danio rerio [Reaction:R-SSC-8865275] PDGF-BB clevage by Furin - Sus scrofa [Reaction:R-BTA-8865275] PDGF-BB clevage by Furin - Bos taurus [Reaction:R-CFA-8865275] PDGF-BB clevage by Furin - Canis familiaris [Reaction:R-RNO-8865275] PDGF-BB clevage by Furin - Rattus norvegicus [Reaction:R-MMU-8865275] PDGF-BB clevage by Furin - Mus musculus
output	[Complex:R-HSA-184206] active PDGF-BB dimer [extracellular region] 2 × [DefinedSet:R-HSA-389066] Cleaved PDGF-B peptides [Golgi lumen]
precedingEvent	[Reaction:R-HSA-382053] Translocation of PDGF from ER to Golgi - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:382617] Heldin, CH, 2008-11-23 19:29:34
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8865275
summation	[Summation:380728] After dimerization of the PDGF-A and PDGF-B chains in the ER...

Referrals

(hasEvent)	[Pathway:R-HSA-186797] Signaling by PDGF
(precedingEvent)	[BlackBoxEvent:R-HSA-186773] PDGF dimer binds two receptors simultaneously