Reactome | IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol

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IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023958] inositol hexakisphosphate kinase activity of IP6K1/3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
crossReference	[DatabaseIdentifier:12667484] RHEA:12794
dbId	1855227
displayName	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol - Homo sapiens
followingEvent	[Reaction:R-HSA-1855158] 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol - Homo sapiens [Reaction:R-HSA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Homo sapiens [Reaction:R-HSA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-1629770] IP6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889803] Identification and characterization of a novel inositol hexakisphosphate kinase [LiteratureReference:1889868] A conserved family of enzymes that phosphorylate inositol hexakisphosphate [LiteratureReference:1889876] Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups [LiteratureReference:1889794] Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
orthologousEvent	[Reaction:R-PFA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Plasmodium falciparum [Reaction:R-DDI-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Dictyostelium discoideum [Reaction:R-SCE-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Saccharomyces cerevisiae [Reaction:R-RNO-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Rattus norvegicus [Reaction:R-CFA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Canis familiaris [Reaction:R-DRE-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Danio rerio [Reaction:R-SSC-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Sus scrofa [Reaction:R-SPO-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Schizosaccharomyces pombe [Reaction:R-CEL-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Caenorhabditis elegans [Reaction:R-DME-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Drosophila melanogaster [Reaction:R-GGA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Gallus gallus [Reaction:R-XTR-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Xenopus tropicalis [Reaction:R-BTA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Bos taurus [Reaction:R-MMU-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Mus musculus
output	[SimpleEntity:R-ALL-1629765] 5-PP-IP5 [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Homo sapiens [Reaction:R-HSA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Homo sapiens [Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855227
summation	[Summation:2023956] Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) pho...

Referrals

(precedingEvent)	[Reaction:R-HSA-1855158] 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol [Reaction:R-HSA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-HSA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
(hasEvent)	[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol

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