Reactome | IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol

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IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10271871] inositol hexakisphosphate kinase activity of IP6K1/3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10271873
displayName	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
eventOf	[Pathway:R-CFA-1855167] Synthesis of pyrophosphates in the cytosol - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1855158] 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol - Canis familiaris [Reaction:R-CFA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Canis familiaris [Reaction:R-CFA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol - Canis familiaris
inferredFrom	[Reaction:R-HSA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-1629770] IP6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
output	[SimpleEntity:R-ALL-1629765] 5-PP-IP5 [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-CFA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Canis familiaris [Reaction:R-CFA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Canis familiaris [Reaction:R-CFA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1855227
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1855167] Synthesis of pyrophosphates in the cytosol
(precedingEvent)	[Reaction:R-CFA-1855158] 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol [Reaction:R-CFA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-CFA-1855182] 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
(inferredTo)	[Reaction:R-HSA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol