Reactome | IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol

IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol

Stable Identifier

R-HSA-1855227

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol

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Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) phosphorylate inositol 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5).

The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008; Lin et al. 2009) and IP6K3 (Saiardi et al. 2001, Draskovic et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18981179	Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases Lin, H, Fridy, PC, Ribeiro, AA, Choi, JH, Barma, DK, Vogel, G, Falck, JR, Shears, SB, York, JD, Mayr, GW	J Biol Chem	2009
18355727	Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups Draskovic, P, Saiardi, A, Bhandari, R, Burton, A, Ilc, G, Kovacevic, M, Snyder, SH, Podobnik, M	Chem Biol	2008
11502751	Identification and characterization of a novel inositol hexakisphosphate kinase Saiardi, A, Nagata, E, Luo, HR, Snowman, AM, Snyder, SH	J Biol Chem	2001
17412958	A conserved family of enzymes that phosphorylate inositol hexakisphosphate Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, York, JD	Science	2007