Reactome | IP6 [cytosol]

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IP6 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-PFA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Plasmodium falciparum [Reaction:R-DDI-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Dictyostelium discoideum [Reaction:R-PFA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Plasmodium falciparum [Reaction:R-SCE-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Saccharomyces cerevisiae [Reaction:R-SCE-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Saccharomyces cerevisiae [Reaction:R-RNO-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Rattus norvegicus [Reaction:R-CFA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Canis familiaris [Reaction:R-DRE-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Danio rerio [Reaction:R-DRE-1855188] IP6 transports from the cytosol to the nucleus - Danio rerio [Reaction:R-SPO-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Schizosaccharomyces pombe [Reaction:R-SPO-1855188] IP6 transports from the cytosol to the nucleus - Schizosaccharomyces pombe [Reaction:R-SPO-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Schizosaccharomyces pombe [Reaction:R-CEL-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Caenorhabditis elegans [Reaction:R-CEL-1855188] IP6 transports from the cytosol to the nucleus - Caenorhabditis elegans [Reaction:R-CEL-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Caenorhabditis elegans [Reaction:R-DME-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Drosophila melanogaster [Reaction:R-DME-1855188] IP6 transports from the cytosol to the nucleus - Drosophila melanogaster [Reaction:R-DME-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Drosophila melanogaster [Reaction:R-GGA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Gallus gallus [Reaction:R-GGA-1855188] IP6 transports from the cytosol to the nucleus - Gallus gallus [Reaction:R-GGA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Gallus gallus [Reaction:R-HSA-1855164] IP6 transports from the cytosol to the ER lumen - Homo sapiens [Reaction:R-HSA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Homo sapiens [Reaction:R-HSA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Homo sapiens [Reaction:R-MMU-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Mus musculus [Reaction:R-MMU-1855188] IP6 transports from the cytosol to the nucleus - Mus musculus [Reaction:R-MMU-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Mus musculus [Reaction:R-RNO-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Rattus norvegicus [Reaction:R-RNO-1855188] IP6 transports from the cytosol to the nucleus - Rattus norvegicus [Reaction:R-HSA-1855188] IP6 transports from the cytosol to the nucleus - Homo sapiens [Reaction:R-CFA-1855188] IP6 transports from the cytosol to the nucleus - Canis familiaris [Reaction:R-BTA-1855188] IP6 transports from the cytosol to the nucleus - Bos taurus [Reaction:R-SSC-1855188] IP6 transports from the cytosol to the nucleus - Sus scrofa [Reaction:R-SSC-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Sus scrofa [Reaction:R-SSC-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Sus scrofa [Reaction:R-CFA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Canis familiaris [Reaction:R-BTA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Bos taurus [Reaction:R-BTA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Bos taurus [Reaction:R-XTR-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol - Xenopus tropicalis [Reaction:R-XTR-1855188] IP6 transports from the cytosol to the nucleus - Xenopus tropicalis [Reaction:R-XTR-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol - Xenopus tropicalis [Reaction:R-DDI-9687638] MLKL binds IP4, IP5 and IP6 - Dictyostelium discoideum [Reaction:R-SSC-9687638] MLKL binds IP4, IP5 and IP6 - Sus scrofa [Reaction:R-BTA-9687638] MLKL binds IP4, IP5 and IP6 - Bos taurus [Reaction:R-RNO-9687638] MLKL binds IP4, IP5 and IP6 - Rattus norvegicus [Reaction:R-MMU-9687638] MLKL binds IP4, IP5 and IP6 - Mus musculus [Reaction:R-HSA-9687638] MLKL binds IP4, IP5 and IP6 - Homo sapiens
created	[InstanceEdit:1629767] Williams, MG, 2011-10-03
crossReference	[DatabaseIdentifier:31410] COMPOUND:C01204
dbId	1629770
displayName	IP6 [cytosol]
inDisease	false
maxDepth	1
memberOf	[DefinedSet:R-ALL-9687630] IP4, IP5, IP6 [cytosol]
modified	[InstanceEdit:9760869] D'Eustachio, Peter, 2022-01-04
name	IP6 myo-inositol hexakisphosphate
producedByEvent	[Reaction:R-DDI-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Dictyostelium discoideum [Reaction:R-DDI-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Dictyostelium discoideum [Reaction:R-SCE-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Saccharomyces cerevisiae [Reaction:R-SCE-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Saccharomyces cerevisiae [Reaction:R-DRE-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Danio rerio [Reaction:R-DRE-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Danio rerio [Reaction:R-SPO-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Schizosaccharomyces pombe [Reaction:R-SPO-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Schizosaccharomyces pombe [Reaction:R-CEL-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Caenorhabditis elegans [Reaction:R-CEL-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Caenorhabditis elegans [Reaction:R-DME-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Drosophila melanogaster [Reaction:R-DME-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Drosophila melanogaster [Reaction:R-GGA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Gallus gallus [Reaction:R-GGA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Gallus gallus [Reaction:R-HSA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Homo sapiens [Reaction:R-HSA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Homo sapiens [Reaction:R-MMU-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Mus musculus [Reaction:R-RNO-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Rattus norvegicus [Reaction:R-CFA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Canis familiaris [Reaction:R-BTA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Bos taurus [Reaction:R-SSC-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Sus scrofa [Reaction:R-DRE-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Danio rerio [Reaction:R-XTR-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Xenopus tropicalis [Reaction:R-GGA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol - Gallus gallus [Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Homo sapiens [Reaction:R-MMU-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Mus musculus [Reaction:R-MMU-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Mus musculus [Reaction:R-RNO-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Rattus norvegicus [Reaction:R-RNO-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Rattus norvegicus [Reaction:R-CFA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Canis familiaris [Reaction:R-BTA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Bos taurus [Reaction:R-SSC-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Sus scrofa [Reaction:R-SSC-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Sus scrofa [Reaction:R-CFA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Canis familiaris [Reaction:R-BTA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Bos taurus [Reaction:R-XTR-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Xenopus tropicalis [Reaction:R-XTR-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol - Xenopus tropicalis
referenceEntity	[ReferenceMolecule:chebi:58130] myo-inositol hexakisphosphate(12-) [ChEBI:58130]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-1629770
updateTrackers	[UpdateTracker:9903698] Update Tracker - [SimpleEntity:1629770] IP6 [cytosol] - v80:[add_removeReferenceEntity] [UpdateTracker:9890830] Update Tracker - [SimpleEntity:1629770] IP6 [cytosol] - v52:[addName]

Referrals

(input)	[Reaction:R-DDI-9687638] MLKL binds IP4, IP5 and IP6 [Reaction:R-SSC-9687638] MLKL binds IP4, IP5 and IP6 [Reaction:R-BTA-9687638] MLKL binds IP4, IP5 and IP6 [Reaction:R-RNO-9687638] MLKL binds IP4, IP5 and IP6 [Reaction:R-MMU-9687638] MLKL binds IP4, IP5 and IP6 [Reaction:R-PFA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-DDI-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-PFA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-SCE-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-SCE-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-RNO-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-CFA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-DRE-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-DRE-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-SPO-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-SPO-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-SPO-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-CEL-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-CEL-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-CEL-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-DME-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-DME-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-DME-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-GGA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-GGA-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-GGA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-HSA-9687638] MLKL binds IP4, IP5 and IP6 [Reaction:R-HSA-1855164] IP6 transports from the cytosol to the ER lumen [Reaction:R-HSA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-HSA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-MMU-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-MMU-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-MMU-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-RNO-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-RNO-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-HSA-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-CFA-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-BTA-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-SSC-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-SSC-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-SSC-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-CFA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-BTA-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-BTA-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol [Reaction:R-XTR-1855216] IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol [Reaction:R-XTR-1855188] IP6 transports from the cytosol to the nucleus [Reaction:R-XTR-1855227] IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
(output)	[Reaction:R-DDI-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-DDI-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-SCE-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-SCE-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-DRE-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-DRE-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-SPO-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-SPO-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-CEL-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-CEL-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-DME-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-DME-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-GGA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-GGA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-HSA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-HSA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-MMU-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-RNO-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-CFA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-BTA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-SSC-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-DRE-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-XTR-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-GGA-1855179] I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol [Reaction:R-HSA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-MMU-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-MMU-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-RNO-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-RNO-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-CFA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-BTA-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-SSC-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-SSC-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-CFA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-BTA-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-XTR-1855198] 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol [Reaction:R-XTR-2023971] 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
(hasMember)	[DefinedSet:R-ALL-9687630] IP4, IP5, IP6 [cytosol]
(updatedInstance)	[UpdateTracker:9903698] Update Tracker - [SimpleEntity:1629770] IP6 [cytosol] - v80:[add_removeReferenceEntity] [UpdateTracker:9890830] Update Tracker - [SimpleEntity:1629770] IP6 [cytosol] - v52:[addName]

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