Reactome | Synthesis of IP3 and IP4 in the cytosol

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Synthesis of IP3 and IP4 in the cytosol Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
dbId	1855204
displayName	Synthesis of IP3 and IP4 in the cytosol
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1483249] Inositol phosphate metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:258976] inositol phosphate metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane - Homo sapiens [Reaction:R-HSA-1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol - Homo sapiens [Reaction:R-HSA-1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol - Homo sapiens [Reaction:R-HSA-1855218] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol - Homo sapiens [Reaction:R-HSA-1855213] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane - Homo sapiens [Reaction:R-HSA-1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol - Homo sapiens [Reaction:R-HSA-1855197] I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol - Homo sapiens [Reaction:R-HSA-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Homo sapiens [Reaction:R-HSA-1855159] I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol - Homo sapiens [Reaction:R-HSA-1855169] I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-06-27
literatureReference	[LiteratureReference:1660544] Back in the water: the return of the inositol phosphates [LiteratureReference:1660552] Phosphoinositide signalling in cancer: beyond PI3K and PTEN
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Synthesis of IP3 and IP4 in the cytosol
orthologousEvent	[Pathway:R-PFA-1855204] Synthesis of IP3 and IP4 in the cytosol - Plasmodium falciparum [Pathway:R-SCE-1855204] Synthesis of IP3 and IP4 in the cytosol - Saccharomyces cerevisiae [Pathway:R-SPO-1855204] Synthesis of IP3 and IP4 in the cytosol - Schizosaccharomyces pombe [Pathway:R-DDI-1855204] Synthesis of IP3 and IP4 in the cytosol - Dictyostelium discoideum [Pathway:R-CEL-1855204] Synthesis of IP3 and IP4 in the cytosol - Caenorhabditis elegans [Pathway:R-DME-1855204] Synthesis of IP3 and IP4 in the cytosol - Drosophila melanogaster [Pathway:R-GGA-1855204] Synthesis of IP3 and IP4 in the cytosol - Gallus gallus [Pathway:R-XTR-1855204] Synthesis of IP3 and IP4 in the cytosol - Xenopus tropicalis [Pathway:R-DRE-1855204] Synthesis of IP3 and IP4 in the cytosol - Danio rerio [Pathway:R-SSC-1855204] Synthesis of IP3 and IP4 in the cytosol - Sus scrofa [Pathway:R-BTA-1855204] Synthesis of IP3 and IP4 in the cytosol - Bos taurus [Pathway:R-CFA-1855204] Synthesis of IP3 and IP4 in the cytosol - Canis familiaris [Pathway:R-RNO-1855204] Synthesis of IP3 and IP4 in the cytosol - Rattus norvegicus [Pathway:R-MMU-1855204] Synthesis of IP3 and IP4 in the cytosol - Mus musculus
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1855204
summation	[Summation:2024067] An array of inositol trisphosphate (IP3) and tetrakisphospha...
updateTrackers	[UpdateTracker:9783094] Update Tracker - [Pathway:1855204] Synthesis of IP3 and IP4 in the cytosol - v57:[updateContainedRLE] [UpdateTracker:9783377] Update Tracker - [Pathway:1855204] Synthesis of IP3 and IP4 in the cytosol - v56:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9783094] Update Tracker - [Pathway:1855204] Synthesis of IP3 and IP4 in the cytosol - v57:[updateContainedRLE] [UpdateTracker:9783377] Update Tracker - [Pathway:1855204] Synthesis of IP3 and IP4 in the cytosol - v56:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-1483249] Inositol phosphate metabolism

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