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Synthesis of IP3 and IP4 in the cytosol
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authored
[InstanceEdit:1855226] Williams, MG, 2011-10-28
created
[InstanceEdit:1855226] Williams, MG, 2011-10-28
dbId
1855204
displayName
Synthesis of IP3 and IP4 in the cytosol
edited
[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf
[Pathway:R-HSA-1483249] Inositol phosphate metabolism - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:258976] inositol phosphate metabolic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Homo sapiens
[Reaction:R-HSA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Homo sapiens
[Reaction:R-HSA-1855214] PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane - Homo sapiens
[Reaction:R-HSA-1855153] I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol - Homo sapiens
[Reaction:R-HSA-1855205] I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol - Homo sapiens
[Reaction:R-HSA-1855218] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol - Homo sapiens
[Reaction:R-HSA-1855213] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane - Homo sapiens
[Reaction:R-HSA-1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol - Homo sapiens
[Reaction:R-HSA-1855197] I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol - Homo sapiens
[Reaction:R-HSA-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Homo sapiens
[Reaction:R-HSA-1855159] I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol - Homo sapiens
[Reaction:R-HSA-1855169] I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1660544] Back in the water: the return of the inositol phosphates
[LiteratureReference:1660552] Phosphoinositide signalling in cancer: beyond PI3K and PTEN
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
Synthesis of IP3 and IP4 in the cytosol
orthologousEvent
[Pathway:R-PFA-1855204] Synthesis of IP3 and IP4 in the cytosol - Plasmodium falciparum
[Pathway:R-SCE-1855204] Synthesis of IP3 and IP4 in the cytosol - Saccharomyces cerevisiae
[Pathway:R-SPO-1855204] Synthesis of IP3 and IP4 in the cytosol - Schizosaccharomyces pombe
[Pathway:R-DDI-1855204] Synthesis of IP3 and IP4 in the cytosol - Dictyostelium discoideum
[Pathway:R-CEL-1855204] Synthesis of IP3 and IP4 in the cytosol - Caenorhabditis elegans
[Pathway:R-DME-1855204] Synthesis of IP3 and IP4 in the cytosol - Drosophila melanogaster
[Pathway:R-GGA-1855204] Synthesis of IP3 and IP4 in the cytosol - Gallus gallus
[Pathway:R-XTR-1855204] Synthesis of IP3 and IP4 in the cytosol - Xenopus tropicalis
[Pathway:R-DRE-1855204] Synthesis of IP3 and IP4 in the cytosol - Danio rerio
[Pathway:R-SSC-1855204] Synthesis of IP3 and IP4 in the cytosol - Sus scrofa
[Pathway:R-BTA-1855204] Synthesis of IP3 and IP4 in the cytosol - Bos taurus
[Pathway:R-CFA-1855204] Synthesis of IP3 and IP4 in the cytosol - Canis familiaris
[Pathway:R-RNO-1855204] Synthesis of IP3 and IP4 in the cytosol - Rattus norvegicus
[Pathway:R-MMU-1855204] Synthesis of IP3 and IP4 in the cytosol - Mus musculus
releaseDate
2012-12-04
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1855204
summation
[Summation:2024067] An array of inositol trisphosphate (IP3) and tetrakisphospha...
Referrals
(hasEvent)
[Pathway:R-HSA-1483249] Inositol phosphate metabolism
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