Reactome | I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol

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I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023900] inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity of ITPK1:Mg2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
dbId	1855171
displayName	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855204] Synthesis of IP3 and IP4 in the cytosol - Homo sapiens
followingEvent	[Reaction:R-HSA-1855197] I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol - Homo sapiens [Reaction:R-HSA-1855180] I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol - Homo sapiens [Reaction:R-HSA-1855232] I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol - Homo sapiens [Reaction:R-HSA-1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-994146] I(1,3,4,6)P4 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889864] Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol
orthologousEvent	[Reaction:R-RNO-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Rattus norvegicus [Reaction:R-DDI-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Dictyostelium discoideum [Reaction:R-GGA-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Gallus gallus [Reaction:R-XTR-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Xenopus tropicalis [Reaction:R-DRE-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Danio rerio [Reaction:R-SSC-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Sus scrofa [Reaction:R-BTA-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Bos taurus [Reaction:R-CFA-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Canis familiaris [Reaction:R-MMU-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Mus musculus
output	[SimpleEntity:R-ALL-994123] I(1,3,4)P3 [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-1855197] I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol - Homo sapiens [Reaction:R-HSA-1855169] I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855171
summation	[Summation:2023908] Inositol-tetrakisphosphate 1-kinase (ITPK1) dephosphorylates...

Referrals

(hasEvent)	[Pathway:R-HSA-1855204] Synthesis of IP3 and IP4 in the cytosol
(precedingEvent)	[Reaction:R-HSA-1855180] I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol [Reaction:R-HSA-1855232] I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol [Reaction:R-HSA-1855172] I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol [Reaction:R-HSA-1855197] I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol