Reactome | Synthesis of IP3 and IP4 in the cytosol

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Synthesis of IP3 and IP4 in the cytosol Show undefined attributes

created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11079339
displayName	Synthesis of IP3 and IP4 in the cytosol
eventOf	[Pathway:R-SPO-1483249] Inositol phosphate metabolism - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:258976] inositol phosphate metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SPO-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-SPO-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-SPO-1855218] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol - Schizosaccharomyces pombe [Reaction:R-SPO-1855213] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-1855204] Synthesis of IP3 and IP4 in the cytosol - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of IP3 and IP4 in the cytosol
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-1855204
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-1483249] Inositol phosphate metabolism
(inferredTo)	[Pathway:R-HSA-1855204] Synthesis of IP3 and IP4 in the cytosol

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