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Synthesis of IP3 and IP4 in the cytosol
Stable Identifier
R-HSA-1855204
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
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An array of inositol trisphosphate (IP3) and tetrakisphosphate (IP4) molecules are synthesised by the action of various kinases and phosphatases in the cytosol (Irvine & Schell 2001, Bunney & Katan 2010).
Literature References
PubMed ID
Title
Journal
Year
11331907
Back in the water: the return of the inositol phosphates
Schell, MJ
,
Irvine, RF
Nat Rev Mol Cell Biol
2001
20414202
Phosphoinositide signalling in cancer: beyond PI3K and PTEN
Bunney, TD
,
Katan, M
Nat Rev Cancer
2010
Participants
Events
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
(Homo sapiens)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
(Homo sapiens)
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
(Homo sapiens)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
(Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
(Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol
(Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane
(Homo sapiens)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
(Homo sapiens)
I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
(Homo sapiens)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol
(Homo sapiens)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol
(Homo sapiens)
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
(Homo sapiens)
Participates
as an event of
Inositol phosphate metabolism (Homo sapiens)
Event Information
Go Biological Process
inositol phosphate metabolic process (0043647)
Orthologous Events
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
Synthesis of IP3 and IP4 in the cytosol (Dictyostelium discoideum)
Synthesis of IP3 and IP4 in the cytosol (Drosophila melanogaster)
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
Synthesis of IP3 and IP4 in the cytosol (Mus musculus)
Synthesis of IP3 and IP4 in the cytosol (Plasmodium falciparum)
Synthesis of IP3 and IP4 in the cytosol (Rattus norvegicus)
Synthesis of IP3 and IP4 in the cytosol (Saccharomyces cerevisiae)
Synthesis of IP3 and IP4 in the cytosol (Schizosaccharomyces pombe)
Synthesis of IP3 and IP4 in the cytosol (Sus scrofa)
Synthesis of IP3 and IP4 in the cytosol (Xenopus tropicalis)
Authored
Williams, MG (2011-10-28)
Created
Williams, MG (2011-10-28)
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