Reactome | I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus

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I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus Show undefined attributes

catalystActivity	[CatalystActivity:10951831] inositol-1,3,4,5,6-pentakisphosphate kinase activity of IP6K1/2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10951833
displayName	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
eventOf	[Pathway:R-CEL-1855191] Synthesis of IPs in the nucleus - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Caenorhabditis elegans [Reaction:R-CEL-1855173] 5-PP-IP4 transports from the nucleus to the cytosol - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-2023901] I(1,3,4,5,6)P5 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
output	[SimpleEntity:R-ALL-2023922] 5-PP-IP4 [nucleoplasm] [SimpleEntity:R-ALL-113582] ADP [nucleoplasm]
precedingEvent	[Reaction:R-CEL-1855206] I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Caenorhabditis elegans [Reaction:R-CEL-1855228] I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Caenorhabditis elegans [Reaction:R-CEL-1855185] I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-1855181
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1855191] Synthesis of IPs in the nucleus
(precedingEvent)	[Reaction:R-CEL-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus [Reaction:R-CEL-1855173] 5-PP-IP4 transports from the nucleus to the cytosol
(inferredTo)	[Reaction:R-HSA-1855181] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus