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Schema
>
Reaction
>
Entries
Constitutive dimerization of FGFR4 Y367C mutant
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authored
[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:2012085] Rothfels, K, 2011-11-22
dbId
2012086
disease
[Disease:1500576] breast cancer
[Disease:1500689] cancer
displayName
Constitutive dimerization of FGFR4 Y367C mutant
edited
[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus
[EntityFunctionalStatus:5654481] gain_of_function of FGFR4 Y367C [plasma membrane]
eventOf
[Pathway:R-HSA-1839128] FGFR4 mutant receptor activation - Homo sapiens
followingEvent
[Reaction:R-HSA-2012087] Autocatalytic phosphorylation of FGFR4 Y367C mutant - Homo sapiens
input
2 ×
[EntityWithAccessionedSequence:R-HSA-1614439] FGFR4 Y367C [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1614268] Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines
[LiteratureReference:2011956] The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells
[LiteratureReference:2045073] Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1)
[LiteratureReference:2029809] Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome
[LiteratureReference:2018765] Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Constitutive dimerization of FGFR4 Y367C mutant
normalReaction
[Reaction:R-HSA-190265] FGFR4 binds to FGF
output
[Complex:R-HSA-2011955] FGFR4 Y367C mutant dimer [plasma membrane]
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2012086
summation
[Summation:2046352] The Y367C mutation in FGFR4 was identified in a breast cance...
Referrals
(precedingEvent)
[Reaction:R-HSA-2012087] Autocatalytic phosphorylation of FGFR4 Y367C mutant
(hasEvent)
[Pathway:R-HSA-1839128] FGFR4 mutant receptor activation
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