Reactome | Autocatalytic phosphorylation of FGFR4 Y367C mutant

Schema > Reaction > Entries

Autocatalytic phosphorylation of FGFR4 Y367C mutant Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:2012069] protein tyrosine kinase activity of FGFR4 Y367C mutant dimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2012085] Rothfels, K, 2011-11-22
crossReference	[DatabaseIdentifier:12020748] Mondo:0007254
dbId	2012087
disease	[Disease:1500576] breast cancer [Disease:1500689] cancer
displayName	Autocatalytic phosphorylation of FGFR4 Y367C mutant
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654466] gain_of_function of FGFR4 Y367C mutant dimer [plasma membrane]
eventOf	[Pathway:R-HSA-1839128] FGFR4 mutant receptor activation - Homo sapiens
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2011955] FGFR4 Y367C mutant dimer [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2011956] The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autocatalytic phosphorylation of FGFR4 Y367C mutant
normalReaction	[Reaction:R-HSA-190326] Autocatalytic phosphorylation of FGFR4
output	[Complex:R-HSA-2011990] Activated FGFR4 Y367C mutant [plasma membrane] 10 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-2012086] Constitutive dimerization of FGFR4 Y367C mutant - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2012087
summation	[Summation:2046321] Expression of the FGFR4 Y367C mutant in MDA-MB453 breast can...

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(hasEvent)

[Pathway:R-HSA-1839128] FGFR4 mutant receptor activation

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