Reactome | Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity

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Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:2038941] protein tyrosine kinase activity of FGFR4 enhanced kinase mutant dimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2038947] Rothfels, K, 2012-01-10
crossReference	[DatabaseIdentifier:12020750] Mondo:0005212
dbId	2038944
disease	[Disease:1500689] cancer [Disease:1614291] rhabdomyosarcoma
displayName	Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654468] gain_of_function of FGFR4 enhanced kinase mutant dimers [plasma membrane]
eventOf	[Pathway:R-HSA-1839128] FGFR4 mutant receptor activation - Homo sapiens
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-HSA-2038942] FGFR4 enhanced kinase mutant dimers [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity
normalReaction	[Reaction:R-HSA-190326] Autocatalytic phosphorylation of FGFR4
output	[CandidateSet:R-HSA-2038945] Activated FGFR4 enhanced kinase mutants [plasma membrane] 10 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-2038946] Dimerization of FGFR4 mutants with enhanced kinase activity - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2038944
summation	[Summation:2046319] FGFR4 N535K and FGFR4 V550E have been shown to undergo autop...

Referrals

(hasEvent)

[Pathway:R-HSA-1839128] FGFR4 mutant receptor activation

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