Reactome | Signaling by FGFR2 IIIa TM

Schema > Pathway > Entries

authored	[InstanceEdit:8851707] Rothfels, Karen, 2016-01-08
created	[InstanceEdit:8851707] Rothfels, Karen, 2016-01-08
crossReference	[DatabaseIdentifier:12020831] Mondo:0019796
dbId	8851708
disease	[Disease:2011822] acrocephalosyndactylia
displayName	Signaling by FGFR2 IIIa TM
edited	[InstanceEdit:8851707] Rothfels, Karen, 2016-01-08
eventOf	[Pathway:R-HSA-1839126] FGFR2 mutant receptor activation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-8851710] Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant - Homo sapiens [Reaction:R-HSA-8853320] FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8851693] Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Signaling by FGFR2 IIIa TM
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8853855] Grose, Richard P, 2016-01-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8851708
summation	[Summation:8853067] A soluble truncated form of FGFR2 is aberrantly expressed in...

(hasEvent)

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