Reactome | Signaling by FGFR2 amplification mutants

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Signaling by FGFR2 amplification mutants Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:2023838] Rothfels, K, 2011-12-12
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2023837
disease	[Disease:1500689] cancer
displayName	Signaling by FGFR2 amplification mutants
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
eventOf	[Pathway:R-HSA-1839126] FGFR2 mutant receptor activation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2029988] Dimerization of overexpressed FGFR2 - Homo sapiens [Reaction:R-HSA-2029989] Autocatalytic phosphorylation of overexpressed FGFR2 variants - Homo sapiens [Reaction:R-HSA-2029992] Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants - Homo sapiens [Reaction:R-HSA-2067713] GP369 inhibits activation of amplified FGFR2 signaling - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2015-07-02
literatureReference	[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor [LiteratureReference:2023815] Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets [LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival [LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform [LiteratureReference:2023825] Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs [LiteratureReference:2023829] Immunohistochemical detection of K-sam protein in stomach cancer [LiteratureReference:2023835] Ligand-independent activation of fibroblast growth factor receptor-2 by carboxyl terminal alterations [LiteratureReference:2029804] Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE [LiteratureReference:2029811] Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis [LiteratureReference:2023817] Up-regulation and co-expression of fibroblast growth factor receptors in human gastric cancer
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Signaling by FGFR2 amplification mutants
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2023837
summation	[Summation:2023827] FGFR2 amplifications have been identified in 10% of gastric ...
updateTrackers	[UpdateTracker:9784785] Update Tracker - [Pathway:2023837] Signaling by FGFR2 amplification mutants - v53:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9784785] Update Tracker - [Pathway:2023837] Signaling by FGFR2 amplification mutants - v53:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-1839126] FGFR2 mutant receptor activation

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