Reactome | Signaling by FGFR2 fusions

Schema > Pathway > Entries

authored	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
created	[InstanceEdit:8853332] Rothfels, Karen, 2016-01-22
dbId	8853333
disease	[Disease:1500689] cancer
displayName	Signaling by FGFR2 fusions
edited	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
eventOf	[Pathway:R-HSA-1839126] FGFR2 mutant receptor activation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8853319] FGFR2 fusions dimerize - Homo sapiens [Reaction:R-HSA-8853313] FGFR2 fusions autophosphorylate - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8852972] Identification of targetable FGFR gene fusions in diverse cancers [LiteratureReference:8853002] The transcriptional landscape and mutational profile of lung adenocarcinoma [LiteratureReference:8852945] Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma [LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Signaling by FGFR2 fusions
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8853855] Grose, Richard P, 2016-01-25
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8853333
summation	[Summation:8853070] FGFR2 fusions have been identified in cancers such as lung, ...

(hasEvent)