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STING mediated induction of host immune responses
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authored
[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
created
[InstanceEdit:1834959] Shamovsky, V, 2011-10-26
dbId
1834941
displayName
STING mediated induction of host immune responses
doi
10.3180/REACT_147841.1
edited
[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf
[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:259970] positive regulation of type I interferon production
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-3244647] cGAS binds cytosolic DNA - Homo sapiens
[Reaction:R-HSA-3244614] cGAS produces cyclic GMP-AMP - Homo sapiens
[Reaction:R-HSA-1834951] IFI16 binds cytosolic dsDNA - Homo sapiens
[Reaction:R-HSA-9013869] DDX41 binds bacterial c-di-AMP, c-di-GMP - Homo sapiens
[Reaction:R-HSA-3134822] DDX41 binds viral dsDNA - Homo sapiens
[Reaction:R-HSA-3134800] STING dimerization - Homo sapiens
[BlackBoxEvent:R-HSA-2396009] STING binds c-di-GMP - Homo sapiens
[BlackBoxEvent:R-HSA-3244643] STING binds cyclic GMP-AMP - Homo sapiens
[Pathway:R-HSA-3270619] IRF3-mediated induction of type I IFN - Homo sapiens
[Pathway:R-HSA-3249367] STAT6-mediated induction of chemokines - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022-04-07
literatureReference
[LiteratureReference:2408464] STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
[LiteratureReference:1834930] STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
[LiteratureReference:2396011] STING is a direct innate immune sensor of cyclic di-GMP
[LiteratureReference:2396006] STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
[LiteratureReference:1834943] IFI16 is an innate immune sensor for intracellular DNA
[LiteratureReference:2408491] The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
[LiteratureReference:3508904] STING Recognition of Cytoplasmic DNA Instigates Cellular Defense
[LiteratureReference:2408415] ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
[LiteratureReference:2408467] Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection
[LiteratureReference:2408386] Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
[LiteratureReference:2453978] Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages
[LiteratureReference:2453998] Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
[LiteratureReference:2453986] The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
[LiteratureReference:2453973] Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
[LiteratureReference:3508901] Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
[LiteratureReference:3508911] Species-specific detection of the antiviral small-molecule compound CMA by STING
maxDepth
3
modified
[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name
STING mediated induction of host immune responses
orthologousEvent
[Pathway:R-RNO-1834941] STING mediated induction of host immune responses - Rattus norvegicus
[Pathway:R-CFA-1834941] STING mediated induction of host immune responses - Canis familiaris
[Pathway:R-BTA-1834941] STING mediated induction of host immune responses - Bos taurus
[Pathway:R-SSC-1834941] STING mediated induction of host immune responses - Sus scrofa
[Pathway:R-DRE-1834941] STING mediated induction of host immune responses - Danio rerio
[Pathway:R-XTR-1834941] STING mediated induction of host immune responses - Xenopus tropicalis
[Pathway:R-GGA-1834941] STING mediated induction of host immune responses - Gallus gallus
[Pathway:R-DME-1834941] STING mediated induction of host immune responses - Drosophila melanogaster
[Pathway:R-CEL-1834941] STING mediated induction of host immune responses - Caenorhabditis elegans
[Pathway:R-DDI-1834941] STING mediated induction of host immune responses - Dictyostelium discoideum
[Pathway:R-MMU-1834941] STING mediated induction of host immune responses - Mus musculus
releaseDate
2012-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2422404] D'Eustachio, P, 2012-07-18
[InstanceEdit:3597627] Jin, Lei, 2013-05-21
[InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1834941
summation
[Summation:2408461] STING (stimulator of IFN genes; also known as MITA/ERIS/MPYS...
updateTrackers
[UpdateTracker:9783023] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v57:[updateIndirectRLE]
[UpdateTracker:9776343] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v76:[updateContainedRLE]
[UpdateTracker:9787839] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v44:[updateContainedRLE]
[UpdateTracker:9782132] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v59:[updateIndirectRLE]
[UpdateTracker:9780177] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v63:[updateContainedRLE]
[UpdateTracker:9778849] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v67:[updateIndirectRLE]
[UpdateTracker:9787299] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v45:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9775007] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v80:[updateIndirectRLE]
[UpdateTracker:9780777] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v62:[addHasEvent, updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA
(updatedInstance)
[UpdateTracker:9783023] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v57:[updateIndirectRLE]
[UpdateTracker:9776343] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v76:[updateContainedRLE]
[UpdateTracker:9787839] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v44:[updateContainedRLE]
[UpdateTracker:9782132] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v59:[updateIndirectRLE]
[UpdateTracker:9780177] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v63:[updateContainedRLE]
[UpdateTracker:9778849] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v67:[updateIndirectRLE]
[UpdateTracker:9787299] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v45:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9775007] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v80:[updateIndirectRLE]
[UpdateTracker:9780777] Update Tracker - [Pathway:1834941] STING mediated induction of host immune responses - v62:[addHasEvent, updateContainedRLE]
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