Reactome | IFI16 binds cytosolic dsDNA

Schema > Reaction > Entries

IFI16 binds cytosolic dsDNA Show undefined attributes

authored	[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1834959] Shamovsky, V, 2011-10-26
dbId	1834951
displayName	IFI16 binds cytosolic dsDNA
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-1834941] STING mediated induction of host immune responses - Homo sapiens
followingEvent	[Reaction:R-HSA-1834939] STING recruits TBK1 and IRF3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1834934] IFI16 [cytosol] [DefinedSet:R-NUL-9013802] IFI16 ligands [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1834943] IFI16 is an innate immune sensor for intracellular DNA [LiteratureReference:2453914] Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16 [LiteratureReference:2453933] IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IFI16 binds cytosolic dsDNA
output	[Complex:R-HSA-1834947] dsDNA:IFI16 [cytosol]
relatedSpecies	[Species:5689680] Human herpesvirus 1 [Species:164493] Human immunodeficiency virus 1 [Species:8875362] Listeria monocytogenes [Species:2671785] Vaccinia virus
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2422404] D'Eustachio, P, 2012-07-18 [InstanceEdit:2453959] Jin, Lei, 2012-08-18 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1834951
summation	[Summation:1834955] Interferon (IFN)-inducible IFI16 protein was shown to be cri...
updateTrackers	[UpdateTracker:9780666] Update Tracker - [Reaction:1834951] IFI16 binds cytosolic dsDNA - v62:[add_removeInput] [UpdateTracker:9787784] Update Tracker - [Reaction:1834951] IFI16 binds cytosolic dsDNA - v44:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9780666] Update Tracker - [Reaction:1834951] IFI16 binds cytosolic dsDNA - v62:[add_removeInput] [UpdateTracker:9787784] Update Tracker - [Reaction:1834951] IFI16 binds cytosolic dsDNA - v44:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-1834941] STING mediated induction of host immune responses
(precedingEvent)	[Reaction:R-HSA-1834939] STING recruits TBK1 and IRF3