Reactome | Nef Mediated CD8 Down-regulation

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Nef Mediated CD8 Down-regulation Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
created	[InstanceEdit:182206] Gillespie, ME, 2006-07-06 19:48:37
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	182218
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Nef Mediated CD8 Down-regulation
eventOf	[Pathway:R-HSA-164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160451] negative regulation of defense response to virus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-182186] Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex - Homo sapiens [Reaction:R-HSA-182198] Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex - Homo sapiens [BlackBoxEvent:R-HSA-182171] Degradation of CD8 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2013-03-31
literatureReference	[LiteratureReference:182276] Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta
maxDepth	2
modified	[InstanceEdit:9953540] Gillespie, Marc E, 2025-06-03
name	Nef Mediated CD8 Down-regulation
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-182218
summation	[Summation:182237] Human immunodeficiency virus (HIV) Nef is a membrane-associa...
updateTrackers	[UpdateTracker:9788079] Update Tracker - [Pathway:182218] Nef Mediated CD8 Down-regulation - v44:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9788079] Update Tracker - [Pathway:182218] Nef Mediated CD8 Down-regulation - v44:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

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