Nef Mediated CD8 Down-regulation

Stable Identifier
Homo sapiens
Related Species
Human immunodeficiency virus 1
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Human immunodeficiency virus (HIV) Nef is a membrane-associated protein decreasing surface expression of CD4, CD28, and major histocompatibility complex class I on infected cells. Nef also strongly down-modulates surface expression of the beta-chain of the CD8alphabeta receptor by accelerated endocytosis, while CD8 alpha-chain expression is less affected. Mutational analysis of the cytoplasmic tail of the CD8 beta-chain indicates that an FMK amino acid motif is critical for the Nef-induced endocytosis. Although independent of CD4, endocytosis of the CD8 beta-chain is abrogated by the same mutations in Nef that affect CD4 down-regulation, suggesting common molecular interactions. The ability to down-regulate the human CD8 beta-chain was conserved in HIV-1, HIV-2, and simian immunodeficiency virus SIVmac239 Nef and required an intact AP-2 complex.

Literature References
PubMed ID Title Journal Year
16103193 Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta

Stove, V, Van de Walle, I, Naessens, E, Coene, E, Stove, C, Plum, J, Verhasselt, B

J Virol 2005
Participant Of
Event Information
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
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