Reactome | Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex

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Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:182206] Gillespie, ME, 2006-07-06 19:48:37
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	182186
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex
eventOf	[Pathway:R-HSA-182218] Nef Mediated CD8 Down-regulation - Homo sapiens
followingEvent	[Reaction:R-HSA-182198] Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex - Homo sapiens
input	[Complex:R-HSA-167712] AP-2 Complex [cytosol] [EntityWithAccessionedSequence:R-HSA-167602] ATP6V1H [plasma membrane] [Complex:R-HSA-182194] CD8:Nef Complex [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182276] Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex
output	[Complex:R-HSA-182158] CD8:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-182186
summation	[Summation:200875] The presence of Nef accelerates endocytosis and lysosomal de...

Referrals

(hasEvent)	[Pathway:R-HSA-182218] Nef Mediated CD8 Down-regulation
(precedingEvent)	[Reaction:R-HSA-182198] Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex

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